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Brown dwarfs with well-measured masses, ages, and luminosities provide direct benchmark tests of substellar formation and evolutionary models. We report the first results from a direct imaging survey aiming to find and characterize substellar companions to nearby accelerating stars with the assistance of the Hipparcos–Gaia Catalog of Accelerations (HGCA). In this paper, we present a joint high-contrast imaging and astrometric discovery of a substellar companion to HD 176535 A, a K3.5V main-sequence star aged approximately $3.59_{-1.15}^{+0.87}$ Gyr at a distance of 36.99 ± 0.03 pc. In advance of our high-contrast imaging observations, we combined precision High Accuracy Radial velocity Planet Searcher (HARPS) Radial Velocities (RVs) and HGCA astrometry to predict the potential companion’s location and mass. We thereafter acquired two nights of KeckAO/NIRC2 direct imaging observations in the L′ band, which revealed a companion with a contrast of $\Delta L^{\prime }_p = 9.20\pm 0.06$ mag at a projected separation of ≈0.35 arcsec (≈13 au) from the host star. We revise our orbital fit by incorporating our dual-epoch relative astrometry using the open-source Markov chain Monte Carlo orbit fitting code orvara. We obtain a dynamical mass of $65.9_{-1.7}^{+2.0} M_{\rm Jup}$ that places HD 176535 B firmly in the brown dwarf regime. HD 176535 B is a new benchmark dwarf useful for constraining the evolutionary and atmospheric models of high-mass brown dwarfs. We found a luminosity of $\rm log(\mathit{ L}_{bol}/L_{\odot }) = -5.26\pm 0.07$ and a model-dependent effective temperature of 980 ± 35 K for HD 176535 B. We infer HD 176535 B to be a T dwarf from its mass, age, and luminosity. Our dynamical mass suggests that some substellar evolutionary models may be underestimating luminosity for high-mass T dwarfs. Given its angular separation and luminosity, HD 176535 B would make a promising candidate for Aperture Masking Interferometry with JWST and GRAVITY/Keck Planet Imager and Characterizer, and further spectroscopic characterization with instruments like the CHARIS/SCExAO/Subaru integral field spectrograph.

 

The cell cycle of Caulobacter crescentus involves the polar morphogenesis and an asymmetric cell division driven by precise interactions and regulations of proteins, which makes Caulobacter an ideal model organism for investigating bacterial cell development and differentiation. The abundance of molecular data accumulated on Caulobacter motivates system biologists to analyze the complex regulatory network of cell cycle via quantitative modeling. In this paper, We propose a comprehensive model to accurately characterize the underlying mechanisms of cell cycle regulation based on the study of: a) chromosome replication and methylation; b) interactive pathways of five master regulatory proteins including DnaA, GcrA, CcrM, CtrA, and SciP, as well as novel consideration of their corresponding mRNAs; c) cell cycle-dependent proteolysis of CtrA through hierarchical protease complexes. The temporal dynamics of our simulation results are able to closely replicate an extensive set of experimental observations and capture the main phenotype of seven mutant strains of Caulobacter crescentus . Collectively, the proposed model can be used to predict phenotypes of other mutant cases, especially for nonviable strains which are hard to cultivate and observe. Moreover, the module of cyclic proteolysis is an efficient tool to study the metabolism of proteins with similar mechanisms. 

Benchmark brown dwarf companions with well-determined ages and model-independent masses are powerful tools to test substellar evolutionary models and probe the formation of giant planets and brown dwarfs. Here, we report the independent discovery of HIP 21152 B, the first imaged brown dwarf companion in the Hyades, and conduct a comprehensive orbital and atmospheric characterization of the system. HIP 21152 was targeted in an ongoing high-contrast imaging campaign of stars exhibiting proper-motion changes between Hipparcos and Gaia, and was also recently identified by Bonavita et al. (2022) and Kuzuhara et al. (2022). Our Keck/NIRC2 and SCExAO/CHARIS imaging of HIP 21152 revealed a comoving companion at a separation of 0.″37 (16 au). We perform a joint orbit fit of all available relative astrometry and radial velocities together with the Hipparcos-Gaia proper motions, yielding a dynamical mass of${24}_{-4}^{+6}{M}_{\mathrm{Jup}}$, which is 1–2σlower than evolutionary model predictions. Hybrid grids that include the evolution of cloud properties best reproduce the dynamical mass. We also identify a comoving wide-separation (1837″ or 7.9 × 10⁴au) early-L dwarf with an inferred mass near the hydrogen-burning limit. Finally, we analyze the spectra and photometry of HIP 21152 B using the Saumon & Marley (2008) atmospheric models and a suite of retrievals. The best-fit grid-based models havef_sed= 2, indicating the presence of clouds,T_eff= 1400 K, and$\log g=4.5\mathrm{dex}$. These results are consistent with the object’s spectral type of T0 ± 1. As the first benchmark brown dwarf companion in the Hyades, HIP 21152 B joins the small but growing number of substellar companions with well-determined ages and dynamical masses.